0921. Effect of norepinephrine on intestinal oxygenation during fluid resuscitation of hemorrhagic shock in mice

Introduction Hemorrhagic shock resuscitation aims at maintaining tissue perfusion while waiting for hemorrhage control. Fluid resuscitation remains the first line therapy to improve tissue perfusion but a vasoconstrictor (most often norepinephrine) may be associated to stabilize the mean arterial pressure (MAP) level and avoid hemodilution while waiting for transfusion. However, the arteriolar vasoconstriction induced by norepinephrine could have deleterious effects on tissue perfusion during hypovolemia due to hemorrhage.